Bad Drugs #1: Paracetamol


Paracetamol is classified as a mild analgesic(
member of the group of drugs used to achieve analgesia, relief from pain). It is commonly used for the relief of headaches and inflammation and is a major ingredient in numerous over the counter cold and flu remedies.

Paracetamol is metabolically combined with arachidonic acid (polyunsaturated omega-6 fatty acid) by FAAH (Fatty acid amide hydrolase) to form AM404(an endogenous cannabinoid reuptake inhibitor). This metabolite of paracetamol is a potent agonist at the TRPV1 vanilloid receptor (expressed at high levels in the central nervous system), a weak agonist at both CB1 and CB2 receptors, and an inhibitor of anandamide reuptake.

As a result, Anandamide ( an endogenous cannabinoid neurotransmitter) levels in the body and brain are elevated. In this fashion, paracetamol acts as a pro-drug for a Cannabimimetic metabolite (any substance that is a cannabinoid receptor type 1 {CB1 receptor} agonist). This action may be partially or fully responsible for the analgesic effects of paracetamol.

SO… What is Paracetamol?

Your Answer is: Acetaminophen aka Tylenol

Analysis of national databases show that acetaminophen-associated overdoses account for about 56,000 emergency room visits and 26,000 hospitalizations yearly. Analysis of national mortality files shows 458 deaths occur each year from acetaminophen-associated overdoses; 100 of these are unintentional. The poison surveillance database showed near-doubling in the number of fatalities associated with acetaminophen from 98 in 1997 to 173 in 2001. AERS data describe a number of possible causes for unintentional acetaminophen-associated overdoses. 
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STILL HAVE A HEADACHE? Δ9-THC and CBD, amongst other compounds found in Cannabis Sativa, work symbiotically together to naturally achieve the same effect. Why risk poisoning yourself or your children when there is a safer alternative?



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